The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

Khalid O Alfarouk; Adil H H Bashir; Ahmed N Aljarbou; AbdelRahman M Ramadan; Abdel Khalig Muddathir; Sari T S AlHoufie; Abdelhamid Hifny; Gamal O Elhassan; Muntaser E Ibrahim; Saad S Alqahtani; Shakir D AlSharari; Claudiu T Supuran; Cyril Rauch; Rosa Angela Cardone; Stephan J Reshkin; Stefano Fais; Salvador Harguindey

doi:10.3389/fonc.2019.00075

The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

Front Oncol. 2019 Feb 22:9:75. doi: 10.3389/fonc.2019.00075. eCollection 2019.

Authors

Khalid O Alfarouk^{1

2

3

4}, Adil H H Bashir^{2

5}, Ahmed N Aljarbou^{6

7}, AbdelRahman M Ramadan⁸, Abdel Khalig Muddathir^{2

9}, Sari T S AlHoufie^{3

10}, Abdelhamid Hifny¹¹, Gamal O Elhassan¹², Muntaser E Ibrahim⁵, Saad S Alqahtani¹³, Shakir D AlSharari^{14

15}, Claudiu T Supuran¹⁶, Cyril Rauch¹⁷, Rosa Angela Cardone¹⁸, Stephan J Reshkin¹⁸, Stefano Fais¹⁹, Salvador Harguindey²⁰

Affiliations

¹ Alfarouk Biomedical Research LLC, Tampa, FL, United States.
² Hala Alfarouk Cancer Center, Khartoum, Sudan.
³ Al-Ghad International College for Applied Medical Sciences, Medina, Saudi Arabia.
⁴ American Biosciences, Inc., New York City, NY, United States.
⁵ Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
⁶ College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.
⁷ Al-Ghad International College for Applied Medical Sciences, Jeddah, Saudi Arabia.
⁸ College of Dentistry, Taibah University, Medina, Saudi Arabia.
⁹ Department of Pharmacognosy, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
¹⁰ Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia.
¹¹ Al-Azhar University, Cairo, Egypt.
¹² Unaizah College of Pharmacy, Qassim University, Unaizah, Saudi Arabia.
¹³ Clinical Pharmacy Department, College of pharmacy, Jazan University, Jazan, Saudi Arabia.
¹⁴ Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
¹⁵ Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, United States.
¹⁶ University of Florence, Florence, Italy.
¹⁷ School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom.
¹⁸ Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.
¹⁹ Department of Oncology and Molecular Medicine, National Institute of Health, Rome, Italy.
²⁰ Institute for Clinical Biology and Metabolism, Vitoria, Spain.

Abstract

Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having immuno-modulating properties. This bacterium is an example of a microorganism inducing gastric cancer. Its carcinogenicity depends on bacteria-host related factors. The proper understanding of the biology of HP inducing gastric cancer offers the potential strategy in the managing of HP rather than eradicating it. In this article, we try to summarize the biology of HP-induced gastric cancer and discuss the current pharmacological approach to treat and prevent its carcinogenicity.

Keywords: Helicobacter pylori; gastric cancer; inflammation; pH; pharmacology.

Publication types

Review