GLP-1: Molecular mechanisms and outcomes of a complex signaling system

Neurochem Int. 2019 Sep:128:94-105. doi: 10.1016/j.neuint.2019.04.010. Epub 2019 Apr 17.

Abstract

Meal ingestion provokes the release of hormones and transmitters, which in turn regulate energy homeostasis and feeding behavior. One such hormone, glucagon-like peptide-1 (GLP-1), has received significant attention in the treatment of obesity and diabetes due to its potent incretin effect. In addition to the peripheral actions of GLP-1, this hormone is able to alter behavior through the modulation of multiple neural circuits. Recent work that focused on elucidating the mechanisms and outcomes of GLP-1 neuromodulation led to the discovery of an impressive array of GLP-1 actions. Here, we summarize the many levels at which the GLP-1 signal adapts to different systems, with the goal being to provide a background against which to guide future research.

Keywords: Bariatric surgery; Feeding behavior; Glucagon-like peptide-1; Reward.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / metabolism
  • Feeding Behavior / drug effects
  • Feeding Behavior / physiology*
  • Glucagon-Like Peptide 1 / metabolism*
  • Glucagon-Like Peptide 1 / pharmacology
  • Glucagon-Like Peptide 1 / therapeutic use
  • Humans
  • Obesity / drug therapy
  • Obesity / metabolism
  • Reward*
  • Signal Transduction / drug effects
  • Signal Transduction / physiology*

Substances

  • Glucagon-Like Peptide 1