Initiating the T Cell Response to Liver-Stage Malaria

Komi Gbedande; Robin Stephens

doi:10.1016/j.pt.2019.04.011

Initiating the T Cell Response to Liver-Stage Malaria

Trends Parasitol. 2019 Jul;35(7):489-490. doi: 10.1016/j.pt.2019.04.011. Epub 2019 May 22.

Authors

Komi Gbedande¹, Robin Stephens²

Affiliations

¹ Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0435, USA.
² Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0435, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0435, USA. Electronic address: [email protected].

PMID: 31129040
DOI: 10.1016/j.pt.2019.04.011

Abstract

Kurup et al. (Cell Host Microbe 2019;25:565-577.e6) define the liver-based antigen-presenting cell driving CD8 T cell responses to mosquito transmission of Plasmodium spp., and show direct interaction of CD11c⁺ cells with infected hepatocytes. We discuss this work in context, highlighting gaps and new approaches suggested by the work to target liver-stage vaccine antigens.

Keywords: T cell; dendritic cell; liver; malaria.

Publication types

Kommentar

MeSH terms

Animals
CD8-Positive T-Lymphocytes
Hepatocytes
Liver
Malaria*
Monocytes
Plasmodium*