Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for clinical microbiology in 2014: General view of the pathogens' antibacterial susceptibility

Katsunori Yanagihara; Tetsuya Matsumoto; Nobuki Aoki; Junko Sato; Tomotaro Wakamura; Hiroshi Kiyota; Kazuhiro Tateda; Hideaki Hanaki; Yoshinobu Ohsaki; Satoru Fujiuchi; Manabu Takahashi; Yuji Akiba; Shingo Masunaga; Kenichi Takeuchi; Hiroaki Takeda; Makoto Miki; Toshio Kumagai; Hiroshi Takahashi; Mutsuko Utagawa; Hajime Nishiya; Sayoko Kawakami; Shinobu Ishigaki; Nobuyuki Kobayasi; Jin Takasaki; Kazuhisa Mezaki; Satoshi Iwata; Yasuhiro Katouno; Rika Inose; Yoshihito Niki; Akihiko Kawana; Yuji Fujikura; Makoto Kudo; Tomo Hirano; Masaki Yamamoto; Naoki Miyazawa; Hiroki Tsukada; Sakura Aso; Yoshihiro Yamamoto; Yoshitsugu Iinuma; Hiroshige Mikamo; Yuka Yamagishi; Atsushi Nakamura; Minoru Ohashi; Atsushi Kawabata; Yoshiko Sugaki; Masafumi Seki; Shigeto Hamaguchi; Masahiro Toyokawa; Hiroshi Kakeya; Yasunori Fujikawa; Noriko Mitsuno; Akira Ukimura; Takayuki Miyara; Michio Hayasi; Keiichi Mikasa; Kei Kasahara; Akira Koizumi; Nobuyoshi Korohasi; Takashi Matumoto; Yutaka Yosimura; Yuichi Katanami; Yoshio Takesue; Yasunao Wada; Keisuke Sugimoto; Tsuyoshi Yamamoto; Masao Kuwabara; Masao Doi; Satomi Simizu; Hirokazu Tokuyasu; Satoshi Hino; Kiyoshi Negayama; Hiroshi Mukae; Toshinori Kawanami; Kazuhiro Yatera; Masaki Fujita; Junichi Kadota; Kazufumi Hiramatsu; Yosuke Aoki; Hiroki Magarifuchi; Megumi Oho; Yoshitomo Morinaga; Moritaka Suga; Hiroyuki Muranaka; Jiro Fujita; Futoshi Higa; Masao Tateyama

doi:10.1016/j.jiac.2019.05.006

Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for clinical microbiology in 2014: General view of the pathogens' antibacterial susceptibility

J Infect Chemother. 2019 Sep;25(9):657-668. doi: 10.1016/j.jiac.2019.05.006. Epub 2019 Jun 10.

Authors

Katsunori Yanagihara¹, Tetsuya Matsumoto², Nobuki Aoki², Junko Sato², Tomotaro Wakamura², Hiroshi Kiyota², Kazuhiro Tateda², Hideaki Hanaki³, Yoshinobu Ohsaki⁴, Satoru Fujiuchi⁵, Manabu Takahashi⁵, Yuji Akiba⁶, Shingo Masunaga⁶, Kenichi Takeuchi⁷, Hiroaki Takeda⁸, Makoto Miki⁹, Toshio Kumagai⁹, Hiroshi Takahashi¹⁰, Mutsuko Utagawa¹⁰, Hajime Nishiya¹¹, Sayoko Kawakami¹¹, Shinobu Ishigaki¹¹, Nobuyuki Kobayasi¹², Jin Takasaki¹², Kazuhisa Mezaki¹², Satoshi Iwata¹³, Yasuhiro Katouno¹³, Rika Inose¹³, Yoshihito Niki¹⁴, Akihiko Kawana¹⁵, Yuji Fujikura¹⁵, Makoto Kudo¹⁶, Tomo Hirano¹⁶, Masaki Yamamoto¹⁶, Naoki Miyazawa¹⁷, Hiroki Tsukada¹⁸, Sakura Aso¹⁸, Yoshihiro Yamamoto¹⁹, Yoshitsugu Iinuma²⁰, Hiroshige Mikamo²¹, Yuka Yamagishi²¹, Atsushi Nakamura²², Minoru Ohashi²², Atsushi Kawabata²³, Yoshiko Sugaki²³, Masafumi Seki²⁴, Shigeto Hamaguchi²⁴, Masahiro Toyokawa²⁴, Hiroshi Kakeya²⁵, Yasunori Fujikawa²⁶, Noriko Mitsuno²⁶, Akira Ukimura²⁷, Takayuki Miyara²⁸, Michio Hayasi²⁹, Keiichi Mikasa³⁰, Kei Kasahara³⁰, Akira Koizumi³⁰, Nobuyoshi Korohasi³¹, Takashi Matumoto³¹, Yutaka Yosimura³¹, Yuichi Katanami³², Yoshio Takesue³³, Yasunao Wada³³, Keisuke Sugimoto³⁴, Tsuyoshi Yamamoto³⁵, Masao Kuwabara³⁶, Masao Doi³⁶, Satomi Simizu³⁶, Hirokazu Tokuyasu³⁷, Satoshi Hino³⁷, Kiyoshi Negayama³⁸, Hiroshi Mukae³⁹, Toshinori Kawanami⁴⁰, Kazuhiro Yatera⁴⁰, Masaki Fujita⁴¹, Junichi Kadota⁴², Kazufumi Hiramatsu⁴², Yosuke Aoki⁴³, Hiroki Magarifuchi⁴³, Megumi Oho⁴³, Yoshitomo Morinaga⁴⁴, Moritaka Suga⁴⁵, Hiroyuki Muranaka⁴⁵, Jiro Fujita⁴⁶, Futoshi Higa⁴⁶, Masao Tateyama⁴⁶

Affiliations

¹ The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Nagasaki University School of Medicine, Nagasaki, Japan. Electronic address: [email protected].
² The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
³ The Kitasato Institute, Tokyo, Japan.
⁴ Asahikawa Medical University, Hokkaido, Japan.
⁵ National Hospital Organization Asahikawa Medical Center, Hokkaido, Japan.
⁶ Asahikawa Kosei Hospital, Hokkaido, Japan.
⁷ Iwate Prefectural Central Hospital, Iwate, Japan.
⁸ Saiseikai Yamagata Saisei Hospital, Yamagata, Japan.
⁹ Japanese Red Cross Sendai Hospital, Miyagi, Japan.
¹⁰ Saka General Hospital, Miyagi, Japan.
¹¹ Teikyo University Hospital, Tokyo, Japan.
¹² National Center for Global Health and Medicine, Tokyo, Japan.
¹³ Keio University Hospital, Tokyo, Japan.
¹⁴ Showa University School of Medicine, Tokyo, Japan.
¹⁵ National Defense Medical College Hospital, Saitama, Japan.
¹⁶ Yokohama City University Hospital, Kanagawa, Japan.
¹⁷ Saiseikai Yokohamashi Nanbu Hospital, Kanagawa, Japan.
¹⁸ Niigata City General Hospital, Niigata, Japan.
¹⁹ Toyama University Hospital, Toyama, Japan.
²⁰ Kanazawa Medical University, Ishikawa, Japan.
²¹ Aichi Medical University Hospital, Aichi, Japan.
²² Nagoya City University Hospital, Aichi, Japan.
²³ Toyota Memorial Hospital, Aichi, Japan.
²⁴ Osaka University Hospital, Osaka, Japan.
²⁵ Osaka City University Hospital, Osaka, Japan.
²⁶ Osaka City General Hospital, Osaka, Japan.
²⁷ Osaka Medical College Hospital, Osaka, Japan.
²⁸ Kansai Medical University Hospital, Osaka, Japan.
²⁹ Sumitomo Hospital, Osaka, Japan.
³⁰ Center for Infectious Diseases, Nara Medical University, Nara, Japan.
³¹ Nara Prefectural Gojo Hospital, Nara, Japan.
³² Nara City Hospital, Nara, Japan.
³³ Hyogo College of Medicine Hospital, Hyogo, Japan.
³⁴ Kobe Red Cross Hospital, Hyogo, Japan.
³⁵ Kobe City Nishi-Kobe Medical Center, Hyogo, Japan.
³⁶ Hiroshima Prefectural Hospital, Hiroshima, Japan.
³⁷ Matsue Red Cross Hospital, Shimane, Japan.
³⁸ Kagawa University Hospital, Kagawa, Japan.
³⁹ University of Occupational and Environmental Health Hospital, Fukuoka, Japan; Nagasaki University School of Medicine, Nagasaki, Japan.
⁴⁰ University of Occupational and Environmental Health Hospital, Fukuoka, Japan.
⁴¹ Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
⁴² Oita University Faculty of Medicine, Oita, Japan.
⁴³ Saga University Hospital, Saga, Japan.
⁴⁴ Nagasaki University School of Medicine, Nagasaki, Japan.
⁴⁵ Saiseikai Kumamoto Hospital, Kumamoto, Japan.
⁴⁶ Department of Infectious, Respiratory, and Digestive Medicine, University of the Ryukyus, Okinawa, Japan.

PMID: 31196772
DOI: 10.1016/j.jiac.2019.05.006

Abstract

The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in Japan was conducted by Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2014. The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between January 2014 and April 2015 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical Laboratory Standards Institute. Susceptibility testing was evaluated in 1534 strains (335 Staphylococcus aureus, 264 Streptococcus pneumoniae, 29 Streptococcus pyogenes, 281 Haemophilus influenzae, 164 Moraxella catarrhalis, 207 Klebsiella pneumoniae, and 254 Pseudomonas aeruginosa). Ratio of methicillin-resistant S. aureus was 43.6%, and those of penicillin-susceptible S. pneumoniae was 100%. Among H. influenzae, 8.2% of them were found to be β-lactamase-producing ampicillin-resistant strains, and 49.1% to be β-lactamase-non-producing ampicillin-resistant strains. Extended spectrum β-lactamase-producing K. pneumoniae and multi-drug resistant P. aeruginosa with metallo β-lactamase were 9.2% and 0.4%, respectively.

Keywords: Antimicrobial resistance; Pneumonia; Susceptibility testing.

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Antimicrobial Stewardship
Drug Resistance, Bacterial*
Epidemiological Monitoring*
Haemophilus influenzae / drug effects
Humans
Japan / epidemiology
Klebsiella pneumoniae / drug effects
Methicillin-Resistant Staphylococcus aureus / drug effects
Microbial Sensitivity Tests
Moraxella catarrhalis / drug effects
Pseudomonas aeruginosa / drug effects
Respiratory Tract Infections / microbiology
Respiratory Tract Infections / prevention & control*
Streptococcus pneumoniae / drug effects
Streptococcus pyogenes / drug effects

Substances

Anti-Bacterial Agents