Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

Chem Commun (Camb). 2019 Jun 27;55(53):7671-7674. doi: 10.1039/c9cc02655j.

Abstract

Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.

MeSH terms

  • Drug Delivery Systems*
  • Humans
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Polyesters / chemistry*
  • Polyethylene Glycols / chemistry*
  • Receptors, Antigen / chemistry*

Substances

  • Polyesters
  • Receptors, Antigen
  • polyethylene glycol-poly(lactide-co-glycolide)
  • Polyethylene Glycols