DNMT3A mutations are over-represented in young adults with NPM1 mutated AML and prompt a distinct co-mutational pattern

Leukemia. 2019 Nov;33(11):2741-2746. doi: 10.1038/s41375-019-0502-0. Epub 2019 Jun 17.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • DNA (Cytosine-5-)-Methyltransferases / genetics*
  • DNA Methyltransferase 3A
  • DNA Mutational Analysis
  • Female
  • Humans
  • Karyotype
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Middle Aged
  • Mutation*
  • Nuclear Proteins / genetics*
  • Nucleophosmin
  • Phosphoproteins / genetics
  • Prognosis
  • RNA Splicing Factors / genetics
  • Retrospective Studies
  • Serine-Arginine Splicing Factors / genetics
  • Spliceosomes / metabolism
  • Young Adult

Substances

  • DNMT3A protein, human
  • NPM1 protein, human
  • Nuclear Proteins
  • Phosphoproteins
  • RNA Splicing Factors
  • SF3B1 protein, human
  • Nucleophosmin
  • SRSF2 protein, human
  • Serine-Arginine Splicing Factors
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methyltransferase 3A