Identification of the amino acids in the Major Histocompatibility Complex class II region of Scottish Blackface sheep that are associated with resistance to nematode infection

Int J Parasitol. 2019 Sep;49(10):797-804. doi: 10.1016/j.ijpara.2019.05.003. Epub 2019 Jul 12.

Abstract

Lambs with the Major Histocompatibility Complex DRB1*1101 allele have been shown to produce fewer nematode eggs following natural and deliberate infection. These sheep also possess fewer adult Teladorsagia circumcincta than sheep with alternative alleles at the DRB1 locus. However, it is unclear if this allele is responsible for the reduced egg counts or merely acts as a marker for a linked gene. This study defined the MHC haplotypes in a population of naturally infected Scottish Blackface sheep by PCR amplification and sequencing, and examined the associations between MHC haplotypes and faecal egg counts by generalised linear mixed modelling. The DRB1*1101 allele occurred predominately on one haplotype and a comparison of haplotypes indicated that the causal mutation or mutations occurred in or around this locus. Additional comparisons with another resistant haplotype indicated that mutations in or around the DQB2*GU191460 allele were also responsible for resistance to nematode infections. Further analyses identified six amino acid substitutions in the antigen binding site of DRB1*1101 that were significantly associated with reductions in the numbers of adult T. circumcincta.

Keywords: Haplotype; Major Histocompatibility Complex; Nematode; Ovine; Scottish Blackface; Sheep; Teladorsagia circumcincta.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / analysis*
  • Amino Acids / immunology
  • Animals
  • Cohort Studies
  • Disease Resistance / genetics
  • Disease Resistance / immunology
  • Feces / parasitology
  • Female
  • Genes, MHC Class II / immunology*
  • Haplotypes
  • Histocompatibility Antigens Class II / chemistry*
  • Linear Models
  • Male
  • Nematode Infections / immunology
  • Nematode Infections / parasitology
  • Nematode Infections / veterinary*
  • Parasite Egg Count / veterinary
  • Polymorphism, Genetic
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / immunology
  • Scotland
  • Sheep
  • Sheep Diseases / immunology*
  • Sheep Diseases / parasitology*
  • Trichostrongyloidea / immunology
  • Trichostrongyloidiasis / immunology
  • Trichostrongyloidiasis / parasitology
  • Trichostrongyloidiasis / veterinary

Substances

  • Amino Acids
  • Histocompatibility Antigens Class II
  • RNA-Binding Proteins