Association Between Zika Virus Microcephaly in Newborns With the rs3775291 Variant in Toll-Like Receptor 3 and rs1799964 Variant at Tumor Necrosis Factor-α Gene

J Infect Dis. 2019 Oct 22;220(11):1797-1801. doi: 10.1093/infdis/jiz392.

Abstract

Congenital Zika syndrome (CZS) is a cluster of malformation, and the mechanisms that lead it are still unclear. Using hypothesis-driven candidate genes and their function in viral infections, single-nucleotide polymorphisms (SNPs) were genotyped by quantitative polymerase chain reaction in a sample population from Sergipe State, Brazil. This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon antiviral responses in mothers infected by Zika virus during pregnancy, is associated with CZS occurrence (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.158-4.148). Moreover, rs1799964 SNP at tumor necrosis factor-α gene in CZS babies is associated with severe microcephaly (OR, 2.63; 95% CI, 1.13-6.21).

Keywords: TLR3; TNFα; congenital Zika syndrome; microcephaly; polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brasilien
  • Female
  • Genotype*
  • Genotyping Techniques
  • Humans
  • Infant, Newborn
  • Male
  • Microcephaly / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Real-Time Polymerase Chain Reaction
  • Toll-Like Receptor 3 / genetics*
  • Tumor Necrosis Factor-alpha / genetics*
  • Young Adult
  • Zika Virus Infection / complications*
  • Zika Virus Infection / genetics*

Substances

  • TLR3 protein, human
  • TNF protein, human
  • Toll-Like Receptor 3
  • Tumor Necrosis Factor-alpha