Cancer remains the second leading cause of death for Guamanians. Guam Cancer Registry (GCR) for two decades has provided epidemiological and demographic data needed to understand the unique cancer burden in Guam. Cancer data, along with data on behavioral risk factors and screening, have helped public health practitioners to target areas of need in cancer prevention, control, and research for Guam and our Pacific neighbors. These targeted efforts enable efficient use of limited resources. While cancer in its many forms remains a formidable foe, we now have a toolbox of evidence-based interventions (EBI), culturally-appropriate programs, community-based coalitions, and research unique to our region. Quality cancer data will remain a key component of this toolbox. This paper reports on the most recent cancer data for Guam for 2007-2015, and Guam's progress toward finding a "cure for cancer" through screening, early detection and treatment, and local research. Together, we can.