Scrutinizing antioxidant interactions between green tea and some medicinal plants commonly used as herbal teas

Meta-analysis reports suggested that green tea (GT) consumption is associated with mild to moderate effects on major global killers. To enhance the health promoting potential of GT, one of the strategies is to combine it with traditionally used medicinal plants (Ocimum gratissimum, Cymbopogon citratus, Cymbopogon flexuosus, and Hibiscus rosa-sinensis). The aim of this investigation was to evaluate and compare the possible synergistic antioxidant interaction of binary combinations of GT with medicinal plants. Overall, GT and O. gratissimum combination showed the highest antioxidant potential and strongest synergistic interaction at EC₅₀ . A strong correlation was found between antioxidant capacity (DPPH, ABTS, NO, and hemolysis) and total phenolic content (TPC) (except lipid peroxidation) for individual infusions, but very weak correlation was observed for GT combinations. Whereas, for both individual and binary aqueous infusions, moderate to strong correlation was observed between antioxidant parameters and FTIR-selected peak (3250-3290 cm^-1 ) omitting lipid peroxidation for single infusions. PRACTICAL APPLICATIONS: The combination of GT with certain medicinal plants used as herbal teas can demonstrate synergistic interactions that may boost the health promoting potential of GT. This study provides basis for future designing and formulation of beverages containing GT combinations based on their antioxidant interactions that can potentially enhance the efficacy of GT as a chemopreventive agent. It may also promote the consumption of GT combinations that may help in realizing untapped potential of underutilized plants.