Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma

J Allergy Clin Immunol. 2020 Jan;145(1):430-433. doi: 10.1016/j.jaci.2019.08.031. Epub 2019 Sep 9.

Abstract

Combination of IL-6 (non-Type 2 asthma) and FeNO or blood eosinophil count (Type 2 asthma) identified asthma endotypes related to asthma severity, exacerbations, and responsiveness to corticosteroids and potential for response to anti-Type 2 and anti-IL-6 treatment.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Asthma / blood*
  • Asthma / immunology
  • Biomarkers / blood
  • Child
  • Female
  • Humans
  • Interleukin-6 / blood*
  • Interleukin-6 / immunology
  • Male
  • Severity of Illness Index

Substances

  • Biomarkers
  • IL6 protein, human
  • Interleukin-6