A TRAV26-1-encoded recognition motif focuses the biased T cell response in celiac disease

Eur J Immunol. 2020 Jan;50(1):142-145. doi: 10.1002/eji.201948235. Epub 2019 Oct 30.

Abstract

The semi-public T-cell response towards the gluten epitope DQ2.5-glia-α2 uses a prototypic TCR encoded by the germline segments TRAV26-1 and TRBV7-2. Through mutagenesis experiments, we show that a TRAV26-1encoded recognition motif contacts the MHC β-chain and the TCR CDR3β loop underpinning this conserved T-cell response restricted to the prototypic TCRs.

Keywords: Celiac disease; Repertoire bias; TCR; TRAV26-1; pMHC recognition.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Motifs / immunology
  • Celiac Disease / immunology*
  • Epitopes, T-Lymphocyte / chemistry
  • Epitopes, T-Lymphocyte / immunology*
  • Humans
  • Lymphocyte Activation / immunology*
  • Receptors, Antigen, T-Cell, alpha-beta / chemistry
  • Receptors, Antigen, T-Cell, alpha-beta / immunology*
  • T-Lymphocytes / immunology*

Substances

  • Epitopes, T-Lymphocyte
  • Receptors, Antigen, T-Cell, alpha-beta