CD38-NAD+-Sirt1 axis in T cell immunotherapy

Aging (Albany NY). 2019 Oct 23;11(20):8743-8744. doi: 10.18632/aging.102385. Epub 2019 Oct 23.
No abstract available

Keywords: T cell; immunotherapy; melanoma; metabolism.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADP-ribosyl Cyclase 1 / genetics
  • ADP-ribosyl Cyclase 1 / metabolism*
  • Cellular Reprogramming
  • Gene Expression Regulation, Neoplastic
  • Genetic Engineering
  • Histones / genetics
  • Histones / metabolism
  • Humans
  • Immunotherapy / methods*
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / metabolism*
  • Mitochondria / metabolism
  • NAD / genetics
  • NAD / metabolism*
  • Neoplasms / therapy
  • Sirtuin 1 / genetics
  • Sirtuin 1 / metabolism*
  • T-Lymphocytes / physiology*
  • Tumor Microenvironment

Substances

  • Histones
  • Membrane Glycoproteins
  • NAD
  • CD38 protein, human
  • ADP-ribosyl Cyclase 1
  • SIRT1 protein, human
  • Sirtuin 1