Statistical modelling of data showing pandemic H1N1 2009 swine influenza a virus infection kinetics in vaccinated pigs

Laetitia Canini; Helen E Everett; Mario Aramouni; Vivien Coward; Andrew Ramsay; Michael Kelly; Sophie Morgan; Elma Tchilian; Sarah Gilbert; Bryan Charleston; Ian H Brown; Sharon M Brookes; Mark E J Woolhouse

doi:10.1016/j.dib.2019.104576

Statistical modelling of data showing pandemic H1N1 2009 swine influenza a virus infection kinetics in vaccinated pigs

Data Brief. 2019 Sep 28:27:104576. doi: 10.1016/j.dib.2019.104576. eCollection 2019 Dec.

Authors

Affiliations

¹ University of Edinburgh, University of Edinburgh, Charlotte Auerbach Road, Edinburgh, EH9 3FL, UK.
² Virology Department, Animal and Plant Health Agency (APHA-Weybridge), New Haw, Addlestone, KT15 3NB, UK.
³ The Jenner Institute, University of Oxford, ORCRB, Roosevelt Drive, Oxford, OX3 7DQ, UK.
⁴ The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.

Abstract

A swine influenza A pandemic 2009 H1N1 (pH1N1) virus was used in a pig challenge model to investigate the efficacy of whole inactivated vaccines homologous or heterologous to the challenge virus as well as a commercial vaccine. Nasal shedding of viral RNA was monitored daily by real-time, quantitative RT-PCR (RRT-qPCR) as detailed (1). Here we report the statistical modelling of the viral RNA shedding kinetics.

Keywords: Pandemic 2009 swine influenza a virus; Statistical modelling RRT-qPCR; Viral kinetics; Whole inactivated vaccine.

Grants and funding

BB/L001330/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom