The NF-κB transcription factor c-Rel controls host defense against Citrobacter rodentium

Maik Luu; Rossana Romero; Jasmin Bazant; Elfadil Abass; Sabrina Hartmann; Hanna Leister; Florence Fischer; Rouzbeh Mahdavi; Carlos Plaza-Sirvent; Ingo Schmitz; Ulrich Steinhoff; Alexander Visekruna

doi:10.1002/eji.201948314

The NF-κB transcription factor c-Rel controls host defense against Citrobacter rodentium

Eur J Immunol. 2020 Feb;50(2):292-294. doi: 10.1002/eji.201948314. Epub 2019 Nov 25.

Authors

Affiliations

¹ Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
² Department of Clinical Laboratory Science, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
³ Institute for Molecular and Clinical Immunology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
⁴ Systems-Oriented Immunology and Inflammation Research Group, Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

PMID: 31724737
DOI: 10.1002/eji.201948314

Abstract

Mice lacking CD4⁺ T cells or B cells are highly susceptible to Citrobacter rodentium infection. In this study, we show that the activity of the transcription factor c-Rel in lymphocytes is crucial for clearance of C. rodentium. Mice deficient for c-Rel fail to generate protective antibodies and to eradicate the pathogen.

Keywords: B cells; CD4+ T cells; Citrobacter rodentium; NF-κB; c-Rel.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Bacterial / immunology
B-Lymphocytes / immunology
CD4-Positive T-Lymphocytes / immunology
Citrobacter rodentium / immunology*
Enterobacteriaceae Infections / immunology*
Mice
NF-kappa B / immunology*
Proto-Oncogene Proteins c-rel / immunology*
Transcription, Genetic / immunology*

Substances

Antibodies, Bacterial
NF-kappa B
Proto-Oncogene Proteins c-rel

Abstract

Publication types

MeSH terms

Substances

Grants and funding