Drug Hepatotoxicity: Causality Assessment

Allyce Caines; Dilip Moonka

doi:10.1016/j.cld.2019.09.001

Drug Hepatotoxicity: Causality Assessment

Clin Liver Dis. 2020 Feb;24(1):25-35. doi: 10.1016/j.cld.2019.09.001. Epub 2019 Oct 31.

Authors

Allyce Caines¹, Dilip Moonka²

Affiliations

¹ Henry Ford Hospital, 2799 West Grand Boulevard, Suite K7, Detroit, MI 48202, USA. Electronic address: [email protected].
² Henry Ford Hospital, 2799 West Grand Boulevard, Suite K7, Detroit, MI 48202, USA. Electronic address: [email protected].

PMID: 31753248
DOI: 10.1016/j.cld.2019.09.001

Abstract

Drug induced liver injury is a diagnosis that relies on the patterns of injury associated with specific medications and toxins. The process by which a clinician determines which agent is the likely culprit of the liver injury is called causality assessment. The Roussel Uclaf Causality Assessment Method (RUCAM) and additional causality assessment methods have been developed with the goal of providing a more standardized, less subjective approach to causality assessment. RUCAM remains the most used standardized method, however many physicians continue to rely on their experience for causality assessment.

Keywords: Causality; Expert opinion; Mario and Victorino; Naranjo; RUCAM.

Publication types

Review

MeSH terms

Causality
Chemical and Drug Induced Liver Injury* / epidemiology
Chemical and Drug Induced Liver Injury* / etiology
Humans
Mediation Analysis*
Risk Assessment* / methods
Risk Assessment* / standards
Risk Factors