Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice

Neuron. 2020 Jan 8;105(1):150-164.e6. doi: 10.1016/j.neuron.2019.10.013. Epub 2019 Nov 18.

Abstract

The generation of myelin-forming oligodendrocytes persists throughout life and is regulated by neural activity. Here we tested whether experience-driven changes in oligodendrogenesis are important for memory consolidation. We found that water maze learning promotes oligodendrogenesis and de novo myelination in the cortex and associated white matter tracts. Preventing these learning-induced increases in oligodendrogenesis without affecting existing oligodendrocytes impaired memory consolidation of water maze, as well as contextual fear, memories. These results suggest that de novo myelination tunes activated circuits, promoting coordinated activity that is important for memory consolidation. Consistent with this, contextual fear learning increased the coupling of hippocampal sharp wave ripples and cortical spindles, and these learning-induced increases in ripple-spindle coupling were blocked when oligodendrogenesis was suppressed. Our results identify a non-neuronal form of plasticity that remodels hippocampal-cortical networks following learning and is required for memory consolidation.

Keywords: Mrf; Oligodendrogenesis; cortex; hippocampus; memory consolidation; myelin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation / physiology*
  • Cerebral Cortex / physiology*
  • Conditioning, Psychological / physiology
  • Electric Stimulation
  • Fear / physiology
  • Female
  • Hippocampus / physiology*
  • Male
  • Maze Learning / physiology
  • Memory Consolidation / physiology*
  • Mice
  • Mice, Transgenic
  • Myelin Sheath / physiology
  • Neural Pathways / physiology
  • Oligodendroglia / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / physiology

Substances

  • Transcription Factors
  • myelin gene regulatory factor, mouse