Benzoazacrown compound: a highly effective chelator for therapeutic bismuth radioisotopes

Medchemcomm. 2019 Jul 4;10(9):1641-1645. doi: 10.1039/c9md00251k. eCollection 2019 Sep 1.

Abstract

A new benzoazacrown ligand H4BATA was synthesized and its complexation ability towards bismuth cations was evaluated. Binding of cation occurs at room temperature in a few minutes and formed complex exhibits the same level of inertness as highly stable complex with the well-known H4DOTA in biologically relevant and challenging media under in vivo conditions.