Randomness is intrinsic to many natural processes. It is also clear that, under certain conditions, disorders are not associated with functionality. Several examples in which overcoming, suppressing, or combining both randomness and non-randomness is required are drawn from various fields. However, the need to suppress or overcome randomness does not negate its importance under certain conditions and its significance in valid processes and organ functions. Randomness should be acknowledged rather than ignored or suppressed; it can be viewed, at worst, as a disturbing disorder that may be treated to produce order, or, at best, as a 'beneficial disorder' that can be considered as a higher level of functionality.