Techniques to Improve Photodynamic Therapy

Photochem Photobiol. 2020 May;96(3):524-528. doi: 10.1111/php.13223. Epub 2020 Mar 5.

Abstract

Photodynamic therapy [dye-light therapy] is an excellent technique for use in detection and treatment of cancerous tissues. While this therapy is effective, it is limited by the phototoxic reactions that can occur in the surrounding normal tissues. These damaging side effects are of particular importance when treating neurosensory organs, such as the human eye. We report here new treatment strategies to enhance photodynamic effectiveness while limiting side effects to normal tissues.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Carcinogens / toxicity
  • Colonic Neoplasms / chemically induced
  • Colonic Neoplasms / drug therapy
  • Dimethylhydrazines / toxicity
  • Eye Diseases / drug therapy
  • Humans
  • Mice, Hairless
  • Mice, Inbred BALB C
  • Photochemotherapy / methods
  • Photochemotherapy / standards*
  • Rats
  • Rats, Wistar
  • Retina / drug effects
  • Urinary Bladder Neoplasms / chemically induced
  • Urinary Bladder Neoplasms / drug therapy

Substances

  • Carcinogens
  • Dimethylhydrazines