Vasorelaxant 4,5-seco-abietane diterpenoids with diverse 6/6/6, 6/6/7, and 6/6/8 architectures from Salvia prattii Hemsl

Fan Xia; Dan Luo; Tingting Wang; Xu Ji; Gang Xu

doi:10.1016/j.fitote.2020.104521

Vasorelaxant 4,5-seco-abietane diterpenoids with diverse 6/6/6, 6/6/7, and 6/6/8 architectures from Salvia prattii Hemsl

Fitoterapia. 2020 Apr:142:104521. doi: 10.1016/j.fitote.2020.104521. Epub 2020 Feb 21.

Authors

Fan Xia¹, Dan Luo², Tingting Wang³, Xu Ji⁴, Gang Xu⁵

Affiliations

¹ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
² Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
³ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, People's Republic of China.
⁴ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, People's Republic of China. Electronic address: [email protected].
⁵ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China. Electronic address: [email protected].

PMID: 32088279
DOI: 10.1016/j.fitote.2020.104521

Abstract

Salpratins A-D (1-4), four new 4,5-seco-abietane diterpenoids, along with twelve known analogues, featuring diverse 6/6/6, 6/6/7, and 6/6/8 rings system, were isolated from Salvia prattii Hemsl. Particularly, salpratin A is the first example of 4,5;12,13-bis-seco-abietane diterpenoid features with a 5/6/6/6 ring system. Their structures were determined by analyses of comprehensive NMR and MS spectroscopic data and single-crystal X-ray diffractions. In addition, compounds 1, 3, 4, 6, 7, 8 and 14 showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.

Keywords: 4,5-seco-Abietane diterpenoid; Salvia prattii; Vasorelaxant activity.

MeSH terms

Abietanes / chemistry
Abietanes / isolation & purification*
Animals
Drug Evaluation, Preclinical
Male
Rats, Sprague-Dawley
Salvia / chemistry*
Vasodilator Agents / chemistry
Vasodilator Agents / isolation & purification*

Substances

Abietanes
Vasodilator Agents