Ototoxicity of cisplatin in gynaecological cancer patients

Scand Audiol. 1988;17(4):241-7. doi: 10.3109/01050398809070712.

Abstract

The ototoxic side effect of a moderate dose of cisplatin was studied by regular audiometric investigations in 186 women with gynaecologic cancer. Cisplatin was given in a dose of 50 mg/m2 body surface by intravenous infusion every 4 weeks. High-frequency hearing loss occurred in 40 patients (22%), but in no single case was a significant change observed in the frequency range of 0.5-2 kHz. Older patients showed a statistically significant greater incidence of audiometric changes, but the pretreatment audiogram was not a predictor for ototoxic changes. It is concluded that a moderate dose of cisplatin does not effect the ability to communicate.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Audiometry, Pure-Tone
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects*
  • Cisplatin / therapeutic use
  • Female
  • Genital Neoplasms, Female / drug therapy*
  • Hearing Loss / chemically induced*
  • Hearing Loss, High-Frequency / chemically induced*
  • Humans
  • Middle Aged
  • Presbycusis / complications

Substances

  • Cisplatin