Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

Affiliations

• ¹ Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. [email protected].
• ² Leeds Institute of Medical Research at St James's, Leeds Institute for Data Analytics, University of Leeds, Leeds, UK.
• ³ Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
• ⁴ Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
• ⁵ Department of Dermatology, Andreas Syggros Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
• ⁶ Genetics of Rare Cancers, Ospedale Policlinico San Martino, Genoa, Italy.
• ⁷ Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa, Italy.
• ⁸ Genetic Epidemiology and Functional Genomics of Multifactorial Diseases Team, Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS-1124, Université Paris Descartes, Paris, France.
• ⁹ Department of Dermatology, Maurizio Bufalini Hospital, Cesena, Italy.
• ¹⁰ Department of Dermatology & Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
• ¹¹ Unit of Immunotherapy of Human Tumors, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
• ¹² Leeds Institute for Data Analytics, University of Leeds, Leeds, UK.
• ¹³ Immunology and Molecular Oncology Unit, Venito Institute of Oncology IOV-IRCCS, Padua, Italy.
• ¹⁴ Red Valenciana de Biobancos, FISABIO, Valencia, Spain.
• ¹⁵ Department of EM/Molecular Pathology & The Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
• ¹⁶ Department of Dermatology, University of Athens School of Medicine, Andreas Sygros Hospital, Athens, Greece.
• ¹⁷ Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia.
• ¹⁸ Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
• ¹⁹ Central Clinical School, The University of Sydney, Sydney, New South Wales, Australia.
• ²⁰ New South Wales Health Pathology, Sydney, New South Wales, Australia.
• ²¹ Dermatology Department, Melanoma Unit, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, CIBERER, Barcelona, Spain.
• ²² Medical Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
• ²³ Pathology Unit, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
• ²⁴ Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
• ²⁵ Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
• ²⁶ Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain.
• ²⁷ Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
• ²⁸ Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
• ²⁹ Institute of Dermatology, Catholic University, Rome, Italy.
• ³⁰ Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
• ³¹ Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy.
• ³² Department of Oncology, Giovanni XXIII Hospital, Bergamo, Italy.
• ³³ UQ Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia.
• ³⁴ Department of Dermatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
• ³⁵ Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
• ³⁶ Department of Pathology, Haukeland University Hospital, Bergen, Norway.
• ³⁷ Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
• ³⁸ Department of Pathology, Molecular Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
• ³⁹ Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes, Paris, France.
• ⁴⁰ Department of Dermatology, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv, Israel.
• ⁴¹ Oncogenetics Unit, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
• ⁴² Dermatology Research Centre, The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
• ⁴³ Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
• ⁴⁴ Department of Dermatology, West Herts NHS Trust, Herts, UK.
• ⁴⁵ Sample Processing, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
• ⁴⁶ Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
• ⁴⁷ Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• ⁴⁸ Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
• ⁴⁹ NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
• ⁵⁰ Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia.
• ⁵¹ Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
• ⁵² Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• ⁵³ Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Institut National de la Santé et de la Recherche Médicale (INSERM U1153), Institut National de la Recherche Agronomique (INRA U1125), Conservatoire National des Arts et Métiers, Communauté d'Université Sorbonne Paris Cité, Bobigny, France.
• ⁵⁴ Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA.
• ⁵⁵ Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
• ⁵⁶ Cancer and Population Studies, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
• ⁵⁷ CRUK Manchester Institute, Institute of Inflammation and Repair, University of Manchester, Manchester, UK.
• ⁵⁸ Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands.
• ⁵⁹ Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
• ⁶⁰ Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
• ⁶¹ Translational Research Institute, Institute of Health and Biomedical Innovation, Princess Alexandra Hospital, Queensland University of Technology, Brisbane, Queensland, Australia.
• ⁶² Department of Dermatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
• ⁶³ Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
• ⁶⁴ Department of Surgical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
• ⁶⁵ Nuffield Department of Population Health, University of Oxford, Oxford, UK.
• ⁶⁶ Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• ⁶⁷ Department of Surgery, Clinical Sciences, Lund University, Lund, Sweden.
• ⁶⁸ Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.
• ⁶⁹ Department of Medical Genetics, University of Glasgow, Glasgow, UK.
• ⁷⁰ McGill University and Genome Quebec Innovation Centre, Montreal, Canada.
• ⁷¹ Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
• ⁷² International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
• ⁷³ Department of Public Health, University of Glasgow, Glasgow, UK.
• ⁷⁴ Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
• ⁷⁵ Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, Crawley, Western Australia, Australia.
• ⁷⁶ Cancer Aetiology & Prevention, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
• ⁷⁷ Department of Molecular Diagnostics, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
• ⁷⁸ School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
• ⁷⁹ Department of Oncology/Pathology, Clinical Sciences, Lund University, Lund, Sweden.
• ⁸⁰ Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
• ⁸¹ Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
• ⁸² Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
• ⁸³ Biochemistry and Molecular Genetics Department, Melanoma Unit, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona,CIBERER, Barcelona, Spain.
• ⁸⁴ Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
• ⁸⁵ Inflammatory Bowel Diseases, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
• ⁸⁶ Department of Gastroenterology and Hepatology, Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia.
• ⁸⁷ University of Queensland School of Medicine, Herston Campus, Brisbane, Queensland, Australia.
• ⁸⁸ Department of Dermatology, University Hospital Essen, Essen, Germany.
• ⁸⁹ German Consortium Translational Cancer Research (DKTK), Heidelberg, Germany.
• ⁹⁰ Department of Dermatology, Fachklinik Hornheide, Institute for Tumors of the Skin, University of Münster, Münster, Germany.
• ⁹¹ Queensland Melanoma Project, Princess Alexandra Hospital, The University of Queensland, St Lucia, Queensland, Australia.
• ⁹² Mater Research Institute, The University of Queensland, St Lucia, Queensland, Australia.
• ⁹³ Departments of Epidemiology and Biostatistics, Key Laboratory of Cancer Prevention and Therapy, Tianjin, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P. R. China.
• ⁹⁴ Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
• ⁹⁵ Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
• ⁹⁶ Department of Clinical Genetics, Center of Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
• ⁹⁷ Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
• ⁹⁸ Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• ⁹⁹ Cancer Genome Research Laboratory, Leidos Biomedical Research, Bethesda, MD, USA.
• ¹⁰⁰ Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
• ¹⁰¹ Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ¹⁰² Oncogenomics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
• ¹⁰³ Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
• ¹⁰⁴ Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
• ¹⁰⁵ Cancer Control Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
• ¹⁰⁶ MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
• ¹⁰⁷ Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
• ¹⁰⁸ Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
• ¹⁰⁹ Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
• ¹¹⁰ Centre for Cancer Research, Westmead Institute for Medical Research, Sydney, Australia.
• ¹¹¹ John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
• ¹¹² Royal North Shore Hospital, Sydney, Australia.
• ¹¹³ Cancer Epidemiology and Prevention Research, Sydney School of Public Health, Sydney, Australia.
• ¹¹⁴ Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
• ¹¹⁵ First Department of Internal Medicine, Laikon General Hospital Greece, National and Kapodistrian University of Athens, Athens, Greece.
• ¹¹⁶ Cancer Genomics Program, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
• ¹¹⁷ Leeds Institute for Data Analytics, University of Leeds, Leeds, UK. [email protected].
• ¹¹⁸ Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. [email protected].