TLR2 as a Therapeutic Target in Bacterial Infection

Morgan E Simpson; William A Petri Jr

doi:10.1016/j.molmed.2020.05.006

TLR2 as a Therapeutic Target in Bacterial Infection

Trends Mol Med. 2020 Aug;26(8):715-717. doi: 10.1016/j.molmed.2020.05.006. Epub 2020 Jun 17.

Authors

Morgan E Simpson¹, William A Petri Jr²

Affiliations

¹ Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA.
² Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA. Electronic address: [email protected].

Abstract

Toll-like receptor (TLR) 2 recognizes and responds to threats early in bacterial infections and can influence the downstream immune response to the host's benefit or detriment. Therapeutic modulation of TLR2 signaling represents an underutilized opportunity to moderate the immune response to infection to promote an improved outcome for the host.

Keywords: TLR2; bacterial infection; immunotherapy; innate immunity.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Bacterial Infections / immunology
Bacterial Infections / metabolism*
Humans
Immunity / immunology
Signal Transduction / immunology
Signal Transduction / physiology
Toll-Like Receptor 2 / immunology
Toll-Like Receptor 2 / metabolism*

Substances

Toll-Like Receptor 2

Abstract

Publication types

MeSH terms

Substances

Grants and funding