Anosmia in COVID-19 Associated with Injury to the Olfactory Bulbs Evident on MRI

AJNR Am J Neuroradiol. 2020 Sep;41(9):1703-1706. doi: 10.3174/ajnr.A6675. Epub 2020 Jun 25.

Abstract

Patients with coronavirus disease 2019 (COVID-19) may have symptoms of anosmia or partial loss of the sense of smell, often accompanied by changes in taste. We report 5 cases (3 with anosmia) of adult patients with COVID-19 in whom injury to the olfactory bulbs was interpreted as microbleeding or abnormal enhancement on MR imaging. The patients had persistent headache (n = 4) or motor deficits (n = 1). This olfactory bulb injury may be the mechanism by which the Severe Acute Respiratory Syndrome coronavirus 2 causes olfactory dysfunction.

MeSH terms

  • Betacoronavirus*
  • COVID-19
  • Coronavirus Infections / complications*
  • Coronavirus Infections / diagnostic imaging
  • Humans
  • Magnetic Resonance Imaging
  • Olfaction Disorders / diagnostic imaging
  • Olfaction Disorders / etiology*
  • Olfactory Bulb / diagnostic imaging*
  • Olfactory Bulb / injuries
  • Pandemics
  • Pneumonia, Viral / complications*
  • Pneumonia, Viral / diagnostic imaging
  • SARS-CoV-2
  • Smell
  • Taste