Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up of Exocrine Pancreatic Ductal Adenocarcinoma: Evidence Evaluation and Recommendations by the Italian Association of Medical Oncology (AIOM)

Nicola Silvestris; Oronzo Brunetti; Alessandro Bittoni; Ivana Cataldo; Domenico Corsi; Stefano Crippa; Mirko D'Onofrio; Michele Fiore; Elisa Giommoni; Michele Milella; Raffaele Pezzilli; Enrico Vasile; Michele Reni

doi:10.3390/cancers12061681

Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up of Exocrine Pancreatic Ductal Adenocarcinoma: Evidence Evaluation and Recommendations by the Italian Association of Medical Oncology (AIOM)

Cancers (Basel). 2020 Jun 24;12(6):1681. doi: 10.3390/cancers12061681.

Authors

Nicola Silvestris^{1

2}, Oronzo Brunetti¹, Alessandro Bittoni³, Ivana Cataldo⁴, Domenico Corsi⁵, Stefano Crippa⁶, Mirko D'Onofrio⁷, Michele Fiore⁸, Elisa Giommoni⁹, Michele Milella¹⁰, Raffaele Pezzilli¹¹, Enrico Vasile¹², Michele Reni¹³

Affiliations

¹ Medical Oncology Unit-IRCCS IstitutoTumori "Giovanni Paolo II" of Bari, 70124 Bari, Italy.
² Department of Biomedical Sciences and Human Oncology-University of Bari Medical School, 70124 Bari, Italy.
³ Oncology Clinic, AOU Ospedali Riuniti, Polytechnic University of Marche, 60121 Ancona, Italy.
⁴ Department of Pathology, Hospital Cà Foncello of Treviso, 31100 Treviso, Italy.
⁵ Medical Oncology Unit Azienda Ospedaliera San Giovanni Calibita Fatebene fratelli Roma, 00186 Roma, Italy.
⁶ Division of Pancreatic Surgery, Vita-Salute University, San Raffaele Scientific Institute, 20132 Milan, Italy.
⁷ Department of Radiology, G. B. Rossi University Hospital, University of Verona, 37129 Verona, Italy.
⁸ Radiation Oncology, Campus Bio-Medico University, 00128 Rome, Italy.
⁹ Medical Oncology Unit, Department of Oncology and Robotic Surgery, AOU Careggi, 50139 Florence, Italy.
¹⁰ Section of Medical Oncology, Department of Medicine, University of Verona and University Hospital Trust, 37129 Verona, Italy.
¹¹ Department of Gastroenterology, San Carlo Hospital, 85100 Potenza, Italy.
¹² Division of Medical Oncology, Pisa University Hospital, 56124 Pisa, Italy.
¹³ Department of Medical Oncology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in women (7%) and the sixth in men (5%) in Italy, with a life expectancy of around 5% at 5 years. From 2010, the Italian Association of Medical Oncology (AIOM) developed national guidelines for several cancers. In this report, we report a summary of clinical recommendations of diagnosis, treatment and follow-up of PDAC, which may guide physicians in their current practice. A panel of AIOM experts in upper gastrointestinal cancer malignancies discussed the available scientific evidence supporting the clinical recommendations.

Keywords: diagnosis; follow-up; guidelines; pancreatic ductal adenocarcinoma; recommendations; treatment.

Publication types

Review