Sex and gender: modifiers of health, disease, and medicine

Lancet. 2020 Aug 22;396(10250):565-582. doi: 10.1016/S0140-6736(20)31561-0.

Abstract

Clinicians can encounter sex and gender disparities in diagnostic and therapeutic responses. These disparities are noted in epidemiology, pathophysiology, clinical manifestations, disease progression, and response to treatment. This Review discusses the fundamental influences of sex and gender as modifiers of the major causes of death and morbidity. We articulate how the genetic, epigenetic, and hormonal influences of biological sex influence physiology and disease, and how the social constructs of gender affect the behaviour of the community, clinicians, and patients in the health-care system and interact with pathobiology. We aim to guide clinicians and researchers to consider sex and gender in their approach to diagnosis, prevention, and treatment of diseases as a necessary and fundamental step towards precision medicine, which will benefit men's and women's health.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Acute Disease / epidemiology
  • Betacoronavirus
  • COVID-19
  • Cause of Death*
  • Chronic Disease / epidemiology
  • Coronavirus Infections / epidemiology
  • Female
  • Health Status*
  • Humans
  • Male
  • Pandemics
  • Pneumonia, Viral / epidemiology
  • Precision Medicine / standards*
  • SARS-CoV-2
  • Sex Characteristics
  • Sex Distribution*
  • Sex Factors