Effects in broiler hens of genetic lines differing in fertility, biotin supplementation, and age on relative abundance of oviductal transforming growth factor-β and carbonic anhydrase mRNA transcripts

Anim Reprod Sci. 2020 Aug:219:106480. doi: 10.1016/j.anireprosci.2020.106480. Epub 2020 May 4.

Abstract

There was evaluation of effects of biotin administration on oviductal abundance of transforming growth factor-β (TGF-β) and carbonic anhydrase (CA) mRNA transcript in younger and older broiler hens of relatively lesser and greater fertility lines. Additionally, effects of biotin supplementation on attenuation of age-related subfertility were evaluated. Hens from the relatively greater (Line D, n = 60) and lesser (Line B, n = 60) fertility rate line were randomly assigned to three treatment groups. Biotin was not or was administered in drinking water from 30 to 33 (younger age) and 53 to 56 (older age) wk of age to have access to no biotin (T0), or 0.3 (T1), or 0.45 (T2) mg/L of biotin. There was assessment the relative oviductal abundances of TGF-β and CA mRNA transcript abundances. Supplemental biotin and age had no effect on the relative abundance of oviductal TGF-β mRNA transcript in hens of Line D. There, however, was a ten-fold greater abundance of TGF-β in hens of the T0 group of Line B compared with Line D. Relative abundance of TGF-β mRNA transcript was greater in younger hens of Line B; however, biotin supplementation of older hens of the T2 group of Line B resulted in a similar TGF-β abundance to that of younger hens. Inconstant with the TGF-β abundance, CA abundance in hens of Line B was not affected by supplemental biotin or bird age. Overall, differences in TGF-β or CA abundances did not affect fertility of broiler hens.

Keywords: Hatchability; Immunity; Reproduction; Sperm storage tubule; Uterovaginal junction.

MeSH terms

  • Age Factors
  • Aging / genetics*
  • Animal Nutritional Physiological Phenomena / drug effects
  • Animals
  • Biotin / pharmacology*
  • Breeding
  • Carbonic Anhydrases / drug effects
  • Carbonic Anhydrases / genetics*
  • Carbonic Anhydrases / metabolism
  • Chickens / genetics
  • Chickens / physiology*
  • Dietary Supplements
  • Female
  • Fertility / genetics
  • Fertility / immunology
  • Gene Expression Regulation / drug effects
  • Oviducts / drug effects
  • Oviducts / metabolism
  • Pedigree
  • RNA, Messenger / drug effects
  • RNA, Messenger / metabolism
  • Reproduction / genetics
  • Reproduction / immunology
  • Transforming Growth Factor beta / drug effects
  • Transforming Growth Factor beta / genetics*
  • Transforming Growth Factor beta / metabolism

Substances

  • RNA, Messenger
  • Transforming Growth Factor beta
  • Biotin
  • Carbonic Anhydrases