Sex and gender aspects in vascular pathophysiology

Clin Sci (Lond). 2020 Aug 28;134(16):2203-2207. doi: 10.1042/CS20200876.

Abstract

Cardiovascular disease (CVD) is a leading cause of global mortality in men and women. The prevalence, pathophysiology, clinical manifestations and outcomes of CVD observed in these two populations is being increasingly recognized as distinct. In this editorial, we provide an overview of mechanisms related to differences in vascular pathophysiology between men and women and explore the contributions of both sex and gender.

Keywords: Gender; Ischaemic heart disease; Sex; Vascular biology.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cardiovascular Agents / therapeutic use
  • Cardiovascular Diseases / diagnosis*
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / therapy
  • Female
  • Genetic Predisposition to Disease / genetics
  • Gonadal Steroid Hormones / metabolism
  • Heart / drug effects
  • Heart / physiopathology*
  • Humans
  • Male
  • Myocardium / metabolism
  • Myocardium / pathology*
  • Risk Assessment / methods
  • Risk Assessment / statistics & numerical data
  • Risk Factors
  • Sex Factors

Substances

  • Cardiovascular Agents
  • Gonadal Steroid Hormones