Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis

Clin Infect Dis. 2021 Jun 1;72(11):e868-e871. doi: 10.1093/cid/ciaa1409.

Abstract

In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.

Keywords: Lewis antigens; blood-group antigens; shigellosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dysentery, Bacillary*
  • Humans
  • Infant
  • Lewis Blood Group Antigens

Substances

  • Lewis Blood Group Antigens