SARS-CoV-2 infection does not induce HIV viral escape in the central nervous system: A case series

C Pinnetti; A Vergori; C Agrati; C Castilletti; P Campioni; R Gagliardini; A Mondi; S Notari; A Amendola; S Cicalini; F Baldini; M R Capobianchi; A Antinori

doi:10.1016/j.ijid.2020.09.040

SARS-CoV-2 infection does not induce HIV viral escape in the central nervous system: A case series

Int J Infect Dis. 2020 Dec:101:38-41. doi: 10.1016/j.ijid.2020.09.040. Epub 2020 Sep 17.

Authors

C Pinnetti¹, A Vergori², C Agrati³, C Castilletti⁴, P Campioni⁵, R Gagliardini⁶, A Mondi⁶, S Notari³, A Amendola⁴, S Cicalini⁶, F Baldini⁶, M R Capobianchi⁴, A Antinori⁶

Affiliations

¹ HIV/AIDS Unit, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy. Electronic address: [email protected].
² HIV/AIDS Unit, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy. Electronic address: [email protected].
³ Cellular Immunology and Pharmacology Laboratory, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy.
⁴ Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy.
⁵ Radiology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
⁶ HIV/AIDS Unit, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy.

Abstract

We report two cases of HIV positive patients with SARS-CoV-2 infection and a recent diagnosis of opportunistic infections of central nervous system (CNS). We investigated the potential impact of coinfection with SARS-CoV-2 on HIV replication in CNS.

Keywords: COVID-19; Central nervous system; HIV infection; HIV viral escape.

Publication types

Case Reports

MeSH terms

Adult
COVID-19 / virology*
Central Nervous System / virology*
Coinfection / virology*
HIV Infections / drug therapy
HIV Infections / virology*
Humans
Male
Middle Aged
SARS-CoV-2*
Viral Load*