Abstract
Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF-/- mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6ТNF-/- mice.
Keywords:
Mycobacterium leprae; leprosy; mice; real time PCR.
MeSH terms
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Adaptive Immunity*
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Animals
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DNA, Bacterial / genetics
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Disease Models, Animal
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Host Specificity
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Humans
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Immunity, Innate*
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Leprosy / genetics
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Leprosy / immunology*
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Leprosy / microbiology
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Leprosy / pathology
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Longevity / genetics
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Longevity / immunology*
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Inbred CBA
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Mice, Knockout
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Mice, Nude
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Mycobacterium leprae / genetics
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Mycobacterium leprae / growth & development
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Mycobacterium leprae / immunology
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Mycobacterium leprae / pathogenicity*
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Tumor Necrosis Factor-alpha / deficiency
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Tumor Necrosis Factor-alpha / genetics
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Tumor Necrosis Factor-alpha / immunology*
Substances
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DNA, Bacterial
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Tumor Necrosis Factor-alpha