Alcohol-free hand sanitizer and other quaternary ammonium disinfectants quickly and effectively inactivate SARS-CoV-2

J Hosp Infect. 2021 Feb:108:142-145. doi: 10.1016/j.jhin.2020.11.023. Epub 2020 Nov 28.

Abstract

Background: SARS-CoV-2 is the virus responsible for the current global pandemic, COVID-19. Because this virus is novel, little is known about its sensitivity to disinfection.

Methods: We performed suspension tests against SARS-CoV-2 using three commercially available quaternary ammonium compound (Quat) disinfectants and one laboratory-made 0.2% benzalkonium chloride solution.

Findings: Three of the four formulations completely inactivated the virus within 15 s of contact, even in the presence of a soil load or when diluted in hard water.

Conclusion: Quats rapidly inactivate SARS-CoV-2, making them potentially useful for controlling SARS-CoV-2 spread in hospitals and the community.

Keywords: COVID-19; Coronavirus; Disinfection; Hand sanitizer; Quaternary ammonium; SARS-CoV-2.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Infective Agents, Local / chemistry
  • Anti-Infective Agents, Local / pharmacology
  • Benzalkonium Compounds / chemistry
  • Benzalkonium Compounds / pharmacology*
  • COVID-19 / diagnosis
  • COVID-19 / epidemiology
  • COVID-19 / prevention & control*
  • COVID-19 / virology
  • Disinfectants / chemistry
  • Disinfectants / classification
  • Disinfectants / pharmacology
  • Disinfection / methods
  • Hand Sanitizers / chemistry
  • Hand Sanitizers / pharmacology*
  • Humans
  • Quaternary Ammonium Compounds / chemistry
  • Quaternary Ammonium Compounds / pharmacology*
  • SARS-CoV-2 / drug effects*
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / growth & development
  • Treatment Outcome

Substances

  • Anti-Infective Agents, Local
  • Benzalkonium Compounds
  • Disinfectants
  • Hand Sanitizers
  • Quaternary Ammonium Compounds