Familial atrial rapid fibrillation associated with double mutations of SCN5A and KCNQ1

Cardiol Young. 2021 Aug;31(8):1356-1358. doi: 10.1017/S1047951121000615. Epub 2021 Feb 26.

Abstract

Familial atrial fibrillation is inherited and sporadically occurs in the paediatric population. Generally, fibrillated wavelets are reported at a frequency of approximately 6 Hz. Herein, we report a familial case presenting rapidly fibrillated wavelets at frequencies of approximately 12 to 30 Hz associated with KCNQ1 and SCN5A mutations.

Keywords: Familial atrial fibrillation; KCNQ1 mutation; SCN5A mutation.

Publication types

  • Case Reports

MeSH terms

  • Atrial Fibrillation* / genetics
  • Child
  • Humans
  • KCNQ1 Potassium Channel* / genetics
  • Mutation
  • NAV1.5 Voltage-Gated Sodium Channel / genetics

Substances

  • KCNQ1 Potassium Channel
  • KCNQ1 protein, human
  • NAV1.5 Voltage-Gated Sodium Channel
  • SCN5A protein, human