NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling

Heidi M Britton; Adrian B Levine; Yaoqing Shen; Karen Mungall; Jonathan Serrano; Matija Snuderl; Erin Pleasance; Steven J M Jones; Janessa Laskin; Marco A Marra; Shahrad R Rassekh; Rebecca Deyell; Stephen Yip; Sylvia Cheng; Chris Dunham

doi:10.1002/ccr3.3804

NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling

Clin Case Rep. 2021 Feb 10;9(3):1472-1477. doi: 10.1002/ccr3.3804. eCollection 2021 Mar.

Authors

Affiliations

¹ Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada.
² Canada's Michael Smith Genome Sciences Centre British Columbia Cancer Agency Vancouver Canada.
³ Department of Pathology New York University School of Medicine New York NY USA.
⁴ Department of Medical Oncology British Columbia Cancer Agency Vancouver BC Canada.
⁵ Division of Pediatric Hematology/Oncology British Columbia Children's Hospital and the University of British Columbia Vancouver BC Canada.
⁶ Division of Anatomic Pathology Children's and Women's Health Centre of British Columbia Vancouver BC Canada.

Abstract

This is the first report of a NACC2-NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profiling in cancer care.

Publication types

Case Reports