Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade

D C W Braeken; A Essig; M Panning; R Hoerster; M Nawrocki; K Dalhoff; N Suttorp; T Welte; M W Pletz; M Witzenrath; G G U Rohde; J Rupp; CAPNETZ- Study Group

doi:10.1007/s15010-021-01605-w

Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade

Infection. 2021 Jun;49(3):533-537. doi: 10.1007/s15010-021-01605-w. Epub 2021 Mar 27.

Authors

D C W Braeken¹, A Essig^#², M Panning³, R Hoerster⁴, M Nawrocki⁵, K Dalhoff⁴, N Suttorp^{5

6}, T Welte^{5

7

8}, M W Pletz^{5

9}, M Witzenrath^{5

6}, G G U Rohde^{5

8

10}, J Rupp^{11

12}; CAPNETZ- Study Group

Collaborators

CAPNETZ- Study Group:
M Dreher, C Cornelissen, W Knüppel, D Stolz, N Suttorp, W Bauer, A Mikolajewska, M Witzenrath, W Pankow, S Gläser, D Thiemig, M Prediger, S Schmager, M Kolditz, B Schulte-Hubbert, S Langner, G Rohde, C Bellinghausen, M Panning, C Hoffmann, T Welte, J Freise, G Barten, W Kröner, M Nawrocki, J Naim, T Illig, N Klopp, M Pletz, C Kroegel, B Schleenvoigt, C Forstner, A Moeser, D Drömann, P Parschke, K Franzen, J Rupp, N Käding, M Wouters, K Walraven, D Braeken, C Spinner, A Zaruchas, D Heigener, I Hering, W Albrich, F Waldeck, F Rassouli, S Baldesberger, S Stenger, M Wallner, H Burgmann, L Traby

Affiliations

¹ Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands.
² Institute of Medical Microbiology and Hygiene, University Hospital of Ulm, Ulm, Germany.
³ Institute of Virology, University Medical Center-University of Freiburg, Freiburg, Germany.
⁴ Medical Clinic III, Pulmonology, University Hospital Schleswig-Holstein, Lübeck, Germany.
⁵ CAPNETZ STIFTUNG, Hannover, Germany.
⁶ Department of Infectious Diseases and Pulmonary Medicine and Division of Pulmonary Inflammation, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁷ Department of Pneumology and German Center for Lung Research (DZL), Hannover Medical School, Hannover, Germany.
⁸ Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.
⁹ Institute for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany.
¹⁰ Department of Respiratory Medicine, Medical Clinic I, Goethe University Hospital, Frankfurt/Main, Germany.
¹¹ CAPNETZ STIFTUNG, Hannover, Germany. [email protected].
¹² Department of Infectious Diseases and Microbiology, University Hospital of Schleswig-Holstein/Campus Lübeck, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany. [email protected].

^# Contributed equally.

Abstract

To determine the most relevant pathogens for CAP in Germany, patients with radiologically confirmed pulmonary infiltrates and at least one clinical sign of lung infection were prospectively recruited within the CAPNETZ cohort from 2004 until 2016. In 990 out of 4.672 patients (21%) receiving complete diagnostics the most prominent change of pathogens was a decrease of S. pneumoniae (58% in 2004 to 37.5% in 2016; p ≤ 0.001, ρ = - 0.148) and an increase of H. influenzae (12.2% to 20.8%; p = 0.001, ρ = 0.104).

Keywords: CAP; Culture; Diagnostics; Pathogens.

MeSH terms

Bacteria
Community-Acquired Infections* / epidemiology
Haemophilus influenzae
Humans
Pneumonia, Bacterial* / diagnosis
Pneumonia, Bacterial* / epidemiology
Streptococcus pneumoniae