COVID-19 is an infectious disease caused by the SARSCoV-2 virus, which has given rise to a global sanitary emergency. The clinical characteristics of COVID-19 are varied and can range from an asymptomatic infection to a mild to severe pneumonia. Recent studies have shown that different laboratory parameters become altered in these patients, and as such are useful as biomarkers to assess the progression of the disease and categorize patients that may present a severe and/or fatal clinical condition. This review analyzes biochemical and immunological markers that become altered in COVID-19 patients and their impact on different organs at a hepatic, cardiac, renal and pancreatic level, as well as markers of inflammation, analyzing their implications in the evolution of the disease.
COVID-19 je infektivno oboljenje izazvano SARS CoV-2 virusom, koje je dovelo do globalne pandemije. Kliničke karakteristike COVID-19 su različite i kreću se od asimptotske infekcije do srednje ili teške pneumonije. Nedavne studije ukazuju da se različiti laboratorijski parametri menjanju kod ovih pacijenata, i kao takvi su korisni kao bio-markeri za praćenje napredovanja oboljenja i kategorizaciju pacijenata koji mogu imati teška i/ili fatalna klinička stanja. U ovom radu su analizirani biohemijski i imunološki markeri koji se menjaju kod COVID-19 pacijenata i pokazatelj su stanja različitih organa kao što su jetra, srce, bubrezi, pankreas, i koriste se kao markeri inflamacije, a za potrebe procene napredovanja i toka oboljenja.
Keywords: COVID-19; SARS-CoV2; biomarkers; coronavirus disease; laboratory diagnosis.
2021 Pablo Letelier, Nicole Encina, Pablo Morales, Alejandra Riffo, Halett Silva, Ismael Riquelme, Neftalí Guzmán, published by CEON/CEES.