Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure

Verena Keitel; Johannes Georg Bode; Torsten Feldt; Andreas Walker; Lisa Müller; Anselm Kunstein; Caroline Klindt; Alexander Killer; Tina Senff; Jörg Timm; Philipp Ostermann; Maximilian Damagnez; Nadine Lübke; Ortwin Adams; Heiner Schaal; Gerald Antoch; Jennifer Neubert; Philipp Albrecht; Sven Meuth; Saskia Elben; Annemarie Mohring; Johannes C Fischer; Edwin Bölke; Manfred Hoenig; Ansgar S Schulz; Tom Luedde; Björn Jensen

doi:10.3389/fimmu.2021.645989

Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure

Front Immunol. 2021 May 3:12:645989. doi: 10.3389/fimmu.2021.645989. eCollection 2021.

Authors

Verena Keitel¹, Johannes Georg Bode¹, Torsten Feldt¹, Andreas Walker², Lisa Müller², Anselm Kunstein¹, Caroline Klindt¹, Alexander Killer¹, Tina Senff², Jörg Timm², Philipp Ostermann², Maximilian Damagnez², Nadine Lübke², Ortwin Adams², Heiner Schaal², Gerald Antoch³, Jennifer Neubert⁴, Philipp Albrecht⁵, Sven Meuth⁵, Saskia Elben⁵, Annemarie Mohring⁶, Johannes C Fischer⁷, Edwin Bölke⁸, Manfred Hoenig⁹, Ansgar S Schulz⁹, Tom Luedde¹, Björn Jensen¹

Affiliations

¹ Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
² Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
³ Department of Diagnostic and Interventional Radiology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
⁴ Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
⁵ Department of Neurology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
⁶ Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
⁷ Institute for Transplant Diagnostics and Cell Therapeutics, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
⁸ Department of Radiation Oncology, University Hospital Duesseldorf, Medical Faculty Heinrich-Heine-University, Duesseldorf, Germany.
⁹ Pediatric Stem Cell Transplantation Unit, University Hospital Ulm, Ulm, Germany.

Abstract

We describe the unique disease course and cure of SARS-CoV-2 infection in a patient with SCID and graft failure. In absence of a humoral immune response, viral clearance was only achieved after transfusion of convalescent plasma. This observation underscores the necessity of the humoral immune response for SARS-CoV-2 clearance.

Keywords: SARS-CoV-2; convalescent plasma; humoral immune response; remdesivir; severe combined immunodeficiency.

Copyright © 2021 Keitel, Bode, Feldt, Walker, Müller, Kunstein, Klindt, Killer, Senff, Timm, Ostermann, Damagnez, Lübke, Adams, Schaal, Antoch, Neubert, Albrecht, Meuth, Elben, Mohring, Fischer, Bölke, Hoenig, Schulz, Luedde and Jensen.

Publication types

Case Reports

MeSH terms

Adult
Antibodies, Viral / blood
COVID-19 / complications
COVID-19 / immunology
COVID-19 / therapy*
COVID-19 / virology
COVID-19 Serotherapy
Female
Graft Rejection / complications
Graft Rejection / immunology
Graft Rejection / virology
Humans
Immunization, Passive
SARS-CoV-2 / physiology*
Severe Combined Immunodeficiency / complications*
Severe Combined Immunodeficiency / immunology
Severe Combined Immunodeficiency / virology
Sustained Virologic Response
Viral Load
Virus Replication

Substances

Antibodies, Viral