Pancreatic plasticity: Unlocking exocrine lineage specification

Jason R Pitarresi; Anil K Rustgi

doi:10.1016/j.stem.2021.05.006

Pancreatic plasticity: Unlocking exocrine lineage specification

Cell Stem Cell. 2021 Jun 3;28(6):987-988. doi: 10.1016/j.stem.2021.05.006.

Authors

Jason R Pitarresi¹, Anil K Rustgi²

Affiliations

¹ Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-5157, USA.
² Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: [email protected].

PMID: 34087158
DOI: 10.1016/j.stem.2021.05.006

Abstract

In this issue of Cell Stem Cell, Huang et al. (2021) and Breunig et al. (2021) developed human stem-cell-derived organoid culture systems to recapitulate pancreatic acinar and ductal lineages. This provides opportunities to study cellular plasticity and transformation in pancreatic cancer initiation and progression.

Publication types

Kommentar

MeSH terms

Acinar Cells
Humans
Organoids
Pancreas
Pancreas, Exocrine*
Pancreatic Ducts
Pancreatic Neoplasms*
Pluripotent Stem Cells*

Abstract

Publication types

MeSH terms

Grants and funding