Bridging the academia-to-industry gap: organ-on-a-chip platforms for safety and toxicology assessment

Trends Pharmacol Sci. 2021 Sep;42(9):715-728. doi: 10.1016/j.tips.2021.05.007. Epub 2021 Jun 27.

Abstract

Some organ-on-a-chip (OoC) systems for drug evaluation show better predictive capabilities than planar, static cell cultures and animal models. One of the ongoing initiatives led by OoC developers is to bridge the academia-to-industry gap in the hope of gaining wider adoption by end-users - academic biological researchers and industry. We discuss several recommendations that can help to drive the adoption of OoC systems by the market. We first review some key challenges faced by OoC developers before highlighting current advances in OoC platforms. We then offer recommendations for OoC developers to promote the uptake of OoC systems by the industry.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Lab-On-A-Chip Devices*
  • Models, Animal