The origins of SARS-CoV-2: A critical review

Cell. 2021 Sep 16;184(19):4848-4856. doi: 10.1016/j.cell.2021.08.017. Epub 2021 Aug 19.

Abstract

Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a "laboratory escape" scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

Keywords: COVID-19; SARS-CoV-2; evolution; origins; zoonosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • COVID-19 / virology
  • Humans
  • Laboratories
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / physiology*
  • Zoonoses / virology