Prognostic value of an echocardiographic index reflecting right ventricular operating stiffness in patients with heart failure

Purpose: We recently reported a noninvasive method for the assessment of right ventricular (RV) operating stiffness that is obtained by dividing the atrial-systolic descent of the pulmonary artery-RV pressure gradient (PRPGD_AC) derived from the pulmonary regurgitant velocity by the tricuspid annular plane movement during atrial contraction (TAPM_AC). Here, we investigated whether this parameter of RV operating stiffness, PRPGD_AC/TAPM_AC, is useful for predicting the prognosis of patients with heart failure (HF).

Methods: We retrospectively included 127 hospitalized patients with HF who underwent an echocardiographic examination immediately pre-discharge. The PRPGD_AC/TAPM_AC was measured in addition to standard echocardiographic parameters. Patients were followed until 2 years post-discharge. The endpoint was the composite of cardiac death, readmission for acute decompensation, and increased diuretic dose due to worsening HF.

Results: 58 patients (46%) experienced the endpoint during follow-up. Univariable and multivariable Cox regression analyses demonstrated that the PRPGD_AC/TAPM_AC was associated with the endpoint. In a Kaplan-Meier analysis, the event rate of the greater PRPGD_AC/TAPM_AC group was significantly higher than that of the lesser PRPGD_AC/TAPM_AC group. In a sequential Cox analysis for predicting the endpoint's occurrence, the addition of PRPGD_AC/TAPM_AC to the model including age, sex, NYHA functional classification, brain natriuretic peptide level, and several echocardiographic parameters including tricuspid annular plane systolic excursion significantly improved the predictive power for prognosis.

Conclusion: A completely noninvasive index of RV operating stiffness, PRPGD_AC/TAPM_AC, was useful for predicting prognoses in patients with HF, and it showed an incremental prognostic value over RV systolic function.