T cells in harmony: Aligning the TCR repertoire pool to identify microbiota recognizing T cells

Amanda Chen; Gretchen E Diehl

doi:10.1016/j.immuni.2021.10.008

T cells in harmony: Aligning the TCR repertoire pool to identify microbiota recognizing T cells

Immunity. 2021 Nov 9;54(11):2437-2439. doi: 10.1016/j.immuni.2021.10.008.

Authors

Amanda Chen¹, Gretchen E Diehl²

Affiliations

¹ Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.
² Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA. Electronic address: [email protected].

PMID: 34758332
DOI: 10.1016/j.immuni.2021.10.008

Abstract

Microbiota-specific T cell responses have been identified for select microbes, but individual T cell receptor repertoire differences make characterizing responses across populations difficult. In this issue of Immunity, Muschaweck et al. establish a system allowing for reproducible responses between individual mice, a powerful tool for characterizing microbiota directed immunity.

Publication types

Kommentar

MeSH terms

Animals
Mice
Microbiota*
Receptors, Antigen, T-Cell
T-Lymphocytes*

Substances

Receptors, Antigen, T-Cell