devfOLD: a toolbox for designing age-specific fNIRS channel placement

Significance: Near-infrared spectroscopy (NIRS) is a noninvasive technique that uses scalp-placed sensors to measure cerebral hemoglobin concentration. Commercial NIRS instruments do not allow for whole-head coverage and do not intrinsically indicate which brain areas generate the NIRS signal. Hence, the challenge is to design source-detector channel arrangement that maximizes sensitivity to a given brain region of interest (ROI). Existing methods for optimizing channel placement design have been developed using adult head models. Thus, they have limited utility for developmental research. Aim: We aim to build an application from an existing toolbox (fOLD) that guides NIRS channel configuration based on age group, stereotaxic atlas, and ROI (devfOLD). Approach: The devfOLD provides NIRS channel-to-ROI specificity computed using photon propagation simulation with realistic head models from infant, child, and adult age groups. Results: Cortical locations and user-specified specificity cut-off values influence the between-age consistency and differences in the ROI-to-channel correspondence among the example infant and adult age groups. Conclusions: The study highlights the importance of incorporating age-specific head models for optimizing NIRS channel configurations. The devfOLD toolbox is publicly shared and compatible with multiple operating systems.