Repeatability and Agreement of Horizontal Corneal Diameter Measurements Between Scanning-Slit Topography, Dual Rotating Scheimpflug Camera With Placido Disc Tomography, Placido Disc Topography, and Optical Coherence Tomography

Purpose: The purpose of this study was to assess the repeatability and agreement of horizontal white-to-white (WTW) measurements using 4 different imaging modalities including a slit-scanning elevation topographer, dual rotating Scheimpflug camera and Placido Disc tomographer, Placido Disc topographer, and anterior segment optical coherence (OCT) tomographer.

Methods: In this prospective study, 33 eyes of 33 healthy subjects were scanned 3 times using each of the Orbscan IIz, Sirius, Nidek OPD III, and DRI OCT Triton devices and WTW measurements were recorded. Repeatability was assessed using the intraclass correlation coefficient (ICC), and agreement was analyzed using Bland-Altman plots.

Results: Mean WTW values obtained from the Orbscan IIz, Sirius, Nidek, and DRI OCT Triton devices were 11.76 ± 0.41, 12.10 ± 0.45, 12.14 ± 0.41, and 12.40 ± 0.48 mm, respectively. Overall, there was high repeatability, with the ICC >0.86 for all devices. The Sirius showed the highest repeatability (ICC = 0.993), and the Nidek the lowest (ICC = 0.870). All pairwise comparison showed significant differences in the mean WTW measurements ( P < 0.01) except between Sirius and Nidek ( P = 0.27). Mean differences showed that the DRI OCT Triton had the highest WTW values, followed by Nidek, Sirius, and finally by Orbscan, which provided the lowest measurements. All pairwise comparisons had wide limits of agreements (between 0.60 and 0.80 mm).

Conclusions: In healthy subjects the 4 devices demonstrated high repeatability in WTW measurement. However, a poor agreement between the devices suggests that they should not be used interchangeably for WTW measurements in clinical practice.