Acute kidney injury in pediatric hematopoietic cell transplantation: critical appraisal and consensus

Pediatr Nephrol. 2022 Jun;37(6):1179-1203. doi: 10.1007/s00467-022-05448-x. Epub 2022 Feb 28.

Abstract

Hematopoietic cell transplantation (HCT) is a common therapy for the treatment of neoplastic and metabolic disorders, hematological diseases, and fatal immunological deficiencies. HCT can be subcategorized as autologous or allogeneic, with each modality being associated with their own benefits, risks, and post-transplant complications. One of the most common complications includes acute kidney injury (AKI). However, diagnosing HCT patients with AKI early on remains quite difficult. Therefore, this evidence-based guideline, compiled by the Pediatric Continuous Renal Replacement Therapy (PCRRT) working group, presents the various factors that contribute to AKI and recommendations regarding optimization of therapy with minimal complications in HCT patients.

Keywords: Acute kidney injury; Bone marrow transplant; Hematopoietic cell transplantation; KRT; Pediatrics; Transplant.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury* / diagnosis
  • Acute Kidney Injury* / etiology
  • Acute Kidney Injury* / therapy
  • Child
  • Consensus
  • Hematopoietic Stem Cell Transplantation* / adverse effects
  • Humans
  • Transplantation, Autologous / adverse effects