A review on the current status and definitions of activity indices in inflammatory bowel disease: how to use indices for precise evaluation

Masahiro Kishi; Fumihito Hirai; Noritaka Takatsu; Takashi Hisabe; Yasumichi Takada; Tsuyoshi Beppu; Ken Takeuchi; Makoto Naganuma; Kazuo Ohtsuka; Kenji Watanabe; Takayuki Matsumoto; Motohiro Esaki; Kazutaka Koganei; Akira Sugita; Keisuke Hata; Kitarou Futami; Yoichi Ajioka; Hiroshi Tanabe; Akinori Iwashita; Hirotaka Shimizu; Katsuhiro Arai; Yasuo Suzuki; Tadakazu Hisamatsu

doi:10.1007/s00535-022-01862-y

A review on the current status and definitions of activity indices in inflammatory bowel disease: how to use indices for precise evaluation

J Gastroenterol. 2022 Apr;57(4):246-266. doi: 10.1007/s00535-022-01862-y. Epub 2022 Mar 2.

Authors

Masahiro Kishi¹, Fumihito Hirai², Noritaka Takatsu¹, Takashi Hisabe³, Yasumichi Takada¹, Tsuyoshi Beppu¹, Ken Takeuchi⁴, Makoto Naganuma⁵, Kazuo Ohtsuka⁶, Kenji Watanabe⁷, Takayuki Matsumoto⁸, Motohiro Esaki⁹, Kazutaka Koganei¹⁰, Akira Sugita¹⁰, Keisuke Hata¹¹, Kitarou Futami¹², Yoichi Ajioka¹³, Hiroshi Tanabe¹⁴, Akinori Iwashita¹⁵, Hirotaka Shimizu¹⁶, Katsuhiro Arai¹⁶, Yasuo Suzuki¹⁷, Tadakazu Hisamatsu¹⁸

Affiliations

¹ Inflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital, Chikushino, Japan.
² Department of Gastroenterology, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan. [email protected].
³ Department of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan.
⁴ Tsujinaka Hospital Kashiwanoha, Kashiwa, Japan.
⁵ The Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
⁶ Department of Endoscopy, Tokyo Medical and Dental University, Tokyo, Japan.
⁷ Center for Inflammatory Bowel Disease, Division of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
⁸ Division of Gastroenterology, Department of Medicine, Iwate Medical University, Iwate, Japan.
⁹ Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
¹⁰ Department of Inflammatory Bowel Disease, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.
¹¹ Nihonbashi Muromachi Mitsui Tower Midtown Clinic, Tokyo, Japan.
¹² Department of Surgery, Fukuoka University Chikushi Hospital, Chikushino, Japan.
¹³ Division of Molecular and Diagnostic Pathology, Graduate School of Medicine and Dental Sciences, Niigata University, Niigata, Japan.
¹⁴ Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
¹⁵ AII Research Institute of Pathology and Image Diagnosis, Fukuoka, Japan.
¹⁶ Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
¹⁷ Ginza Central Clinic, Tokyo, Japan.
¹⁸ Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Tokyo, Japan.

Abstract

Many clinical trials have been conducted for inflammatory bowel disease (IBD), so various clinical indices (CIs) and endoscopic indices (EIs) have also been evaluated. However, recently, with the progress of IBD management, review of established indices from previous studies, and establishment of new indices, the landscape of the use of indices in clinical trials have changed. We investigated the number and frequency of the indices adapted in recent clinical trials for ulcerative colitis (CI and EI) and Crohn's disease (CI, EI, index related to magnetic resonance imaging, index for evaluating patient-reported outcomes, and health-related quality of life). Based on the results, we selected representative indices and further reviewed their content and characteristics. Moreover, various definitions, including clinical and endoscopic response or remission, have been described by means of representative indices in clinical trials.

Keywords: Clinical index; Crohn’s disease; Endoscopic index; Inflammatory bowel disease; Ulcerative colitis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Chronic Disease
Colitis, Ulcerative* / diagnosis
Colitis, Ulcerative* / pathology
Colitis, Ulcerative* / therapy
Crohn Disease* / drug therapy
Endoscopy
Humans
Inflammatory Bowel Diseases* / diagnosis
Inflammatory Bowel Diseases* / therapy
Quality of Life