Selection and Warning of Evidence-Based Antidiabetic Medications for Patients With Chronic Liver Disease

Fu-Shun Yen; Chih-Cheng Hsu; James Cheng-Chung Wei; Ming-Chih Hou; Chii-Min Hwu

doi:10.3389/fmed.2022.839456

Selection and Warning of Evidence-Based Antidiabetic Medications for Patients With Chronic Liver Disease

Front Med (Lausanne). 2022 Feb 16:9:839456. doi: 10.3389/fmed.2022.839456. eCollection 2022.

Authors

Fu-Shun Yen¹, Chih-Cheng Hsu^{2

3

4}, James Cheng-Chung Wei^{5

6

7}, Ming-Chih Hou^{8

9}, Chii-Min Hwu^{8

10}

Affiliations

¹ Dr. Yen's Clinic, Taoyuan, Taiwan.
² Institute of Population Health Sciences, National Health Research Institute, Miaoli, Taiwan.
³ Department of Health Services Administration, China Medical University, Taichung, Taiwan.
⁴ Department of Family Medicine, Min-Sheng General Hospital, Taoyuan, Taiwan.
⁵ Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
⁶ Department of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
⁷ Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
⁸ Institute of Clinical Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan.
⁹ Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
¹⁰ Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Abstract

The global prevalence of chronic liver disease and diabetes mellitus (DM) has gradually increased potentially due to changes in diet and lifestyle. The choice of antidiabetic medications for patients with coexisting DM and chronic liver disease is complicated. Severe liver injury may decrease the metabolism of antidiabetic medications, resulting in elevated drug concentrations and adverse effects. The choice of antidiabetic medications in patients with chronic liver disease has not been well studied. The long-term outcomes of antidiabetic medications in patients with chronic liver disease have gained attention recently. Herein, we reviewed relevant articles to extend our understanding on the selection and warning of antidiabetic medications for patients with chronic liver disease.

Keywords: antidiabetic medication; chronic liver disease; compensated liver cirrhosis; decompensated liver cirrhosis; diabetes mellitus.

Publication types

Review