Acute autonomic dysregulation due to HHV-6 encephalitis in an immunocompromised patient: a case report and literature review

Acta Neurol Belg. 2022 Jun;122(3):583-585. doi: 10.1007/s13760-021-01828-6. Epub 2022 Mar 28.

Abstract

Human herpesvirus-6 (HHV-6), in particularly HHV-6B, can reactivate in immunocompromised patients. Especially after stem cell transplantation, reactivation of HHV-6 can cause complications, such as limbic encephalitis. We present a case of a 61-year-old man with B-cell non-Hodgkin lymphoma. He presented with subacute lethargy, confusion and hyperhidrosis. Following this, we will give a short review of the literature considering clinical and technical features as well as treatment options.

Keywords: Autonomic dysfunction; Foscarnet; Ganciclovir; HHV-6 encephalitis Immunocompromised; Stem cell transplantation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Encephalitis, Viral* / drug therapy
  • Encephalitis, Viral* / etiology
  • Hematopoietic Stem Cell Transplantation*
  • Herpesvirus 6, Human*
  • Humans
  • Immunocompromised Host
  • Male
  • Middle Aged
  • Roseolovirus Infections* / complications
  • Roseolovirus Infections* / drug therapy
  • Roseolovirus Infections* / pathology