Transcribed Ultraconserved Regions in Cancer

Cells. 2022 May 19;11(10):1684. doi: 10.3390/cells11101684.

Abstract

Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives.

Keywords: TUCR; cancer; long non-coding RNA; ultraconserved.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Conserved Sequence / genetics
  • DNA
  • Genome
  • Mice
  • Neoplasms* / genetics
  • RNA, Long Noncoding* / genetics
  • RNA, Long Noncoding* / metabolism
  • Rats

Substances

  • RNA, Long Noncoding
  • DNA